As of 2019, no long-time period human studies evaluating use of Pueraria mirifica and the danger of these or other cancers have been been carried out. Nonetheless, a study reported within the March 2012 subject of the journal Toxicological Sciences discovered that publicity to a phytoestrogen mixture containing two of most plentiful phytoestrogens in Pueraria mirifica promoted the development of mammary and endometrial cancers in rats. Use of phytoestrogens, together with these present in Pueraria mirifica, raises a concern about a potentially elevated danger for hormone-sensitive cancers, including breast, ovarian and endometrial most cancers.
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