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Where To Buy Pueraria Mirifica Herb Hakamatsuka, T., Shinkai, Ok., Noguchi, H., Ebizuka, Y. and Sankawa, U. (1992) Isoflavone Dimers from Yeast Extract-Treated Cell Suspension Cultures of Pueraria lobata. Hakamatsuka T, Shinkai Okay, Noguchi H, Ebizuka Y, Sankawa U. Isoflavone Dimers from Yeast Extract-Treated Cell Suspension Cultures of Pueraria lobata. Figure 5. Pharmacological activities of Pueraria tuberosa. Group 1, treated with 1.5 g (twice a day) tuber powder of P. tuberosa for 12 weeks, showed a gradual lower in systolic, diastolic, and imply blood strain as well as a tolerant decrease in fibrinogen and increased plasma fibrinolytic activity (Verma et al., 2012). In stress-mediated disorders, the hypothalamic-pituitary-adrenal (HPA) axis is dysregulated which adjustments the levels of corticosteroids in plasma and monoamine in the brain. These research indicate that P. tuberosa extracts have nephron-protective potential and might lead to promising therapeutic brokers for treating kidney diseases. Apart from puerarin, daidzein, genistein, irisolidone, and biochanin, many more compounds have been recognized from P. tuberosa; nonetheless, underlying mechanisms of motion of compounds remoted from this plant will not be completely known. Whether or not you might be bulky, tall, slim, pear shaped or excellent shaped with nice curves.

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Secrets On Making Your Skin Soft A-line garment is the commonest and common sample, which enhances the body curve of the ladies. It has been prescribed for treatment for all three doshas (i.e., for the complications of three different energies, viz., Vata, Kapha, and Pitta) of human body (Ayurvedic pharmacopoeia of India, 1999; Dalal et al., 2013). The powdered form of tuber is primarily used together with cow’s milk as a galactagogue agent to abrogate lack of milk manufacturing after childbirth and also as an anabolic agent along with Piper longum L. (Piperaceae) powder to cure malnutrition in kids. Studies also confirmed a substantial decrease in the amount of mature Leydig cells, cauda epididymis, and sperm motility (Gupta et al., 2005). The antioxidant-enriched fraction from the tuber extract of P. tuberosa against menopausal osteoporosis in ovariectomy-induced osteoporosis in rats was studied and found that it improved biochemical parameters, controlled the elevated physique weight, and decreased uterus weight following ovariectomy in addition to restoration of typical bone construction and trabecular width of the femur (Satpathy et al., 2020). Incision and excision wounds have been handled with methanolic and ethyl acetate tuber extract of P. tuberosa. However, the data in regards to the doses of plant extracts used and the fashions implied for the studies (in vitro or in vivo) in several pharmacological actions was missing. It was also effective in opposition to carrageenan-induced inflammation on paw edema and air pouch mouse models. For the workplace parties, you can wear a protracted fitted jacket with this ghagra choli. You possibly can go for sleeveless designer jacket over the noodle strap backless bodice.

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Buy Pueraria Mirifica If you’re considering using Pueraria Mirifica, be sure to comply with the beneficial dosage and frequency, and monitor your progress intently. By following the really helpful dosage and frequency, and being patient with the outcomes, you can achieve the desired enhancements in your appearance. In this part, we will focus on the really useful dosage, frequency, and anticipated results. It’s important not to exceed the advisable dosage, as this can result in opposed results. It’s an efficient various to hormonal therapies, which might have significant negative effects. Pueraria Mirifica is a natural and safer various that has been shown to have helpful results on male breast development before and after therapy. It has been proven to have beneficial effects on male breast progress before and after therapy. Pueraria Mirifica has been shown to have beneficial results on male breast progress before treatment.

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Natural Beast Enhancement Pueraria Mirifica contains phytoestrogens, plant compounds that mimic the effects of estrogen within the physique. Remember, everyone’s body is totally different, and results could fluctuate. As men get older, testosterone levels decrease, Pueraria Mirifica Singapore whereas estrogen levels may stay the identical or enhance.

Some males may start to see outcomes inside just a few weeks, whereas others could take several months. With common use, you may expect to see fuller, firmer, and more symmetrical breasts. Whereas more analysis is needed to fully understand the mechanisms behind its efficacy, the prevailing research and testimonials recommend that it could also be a secure and effective possibility for men trying to reinforce their bodily look.

Effects of Dietary Phytoestrogens on Hormones throughout a Human Lifespan: A Assessment

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Phytoestrogens are polyphenolic molecules with a structural similarity to endogenous human hormones, hence their estrogenic activity. Soy isoflavones appear to not have any influence on sex and thyroid hormones, bone remodeling and IGF. They may also activate serotonergic and insulin-like growth issue (IGF) receptors 1, induce free radical binding and modify tyrosine kinases, cycle adenosine monophosphate (cAMP), phosphatidylinositol-three kinase (PI3K)/Akt, mitogen-activated protein (MAP) kinases, transcription of nuclear factor-kappa β (NF-Kβ), in addition to promote DNA methylation and affect histone and RNA expression. PSA, a protein produced by the prostate gland, is used as a marker to detect PCa, although its levels additionally enhance with benign prostate hypertrophy. In the primary examine, groups of 14 women consumed soy protein isolates providing eight mg (control), sixty five mg (low dose), or 130 mg (excessive dose) of isoflavones day by day for 3 menstrual cycles.

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Other RCTs have used soy isoflavones instead of genistein, administering every day doses of 40-160 mg, far higher than the phytoestrogen intake reported in observational studies. Lastly, outcomes from epidemiological studies support the speculation that some phytoestrogens might have a positive affect on SHBG. Although preclinical studies (in vitro and in animal models) show phytoestrogens to be potentially estrogenic compounds, triggering anti-estrogenic results within the organism, the outcomes of epidemiological studies are ambiguous.

On this assessment, we’ve summarized the results of human research on dietary phytoestrogens with the aim of assessing the doable hormone-dependent outcomes and well being results of their consumption throughout a lifespan, focusing on pregnancy, childhood, adulthood, and the premenopausal and postmenopausal phases.

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This overview has summarized the results of studies on the consequences of dietary phytoestrogens on endocrine regulation in humans.

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Systematic critiques of RCTs present contradictory results, and meta-analyses reveal no statistically vital discount of vasomotor symptoms for phytoestrogens. Individual RCTs report important reductions in vasomotor signs for red clover and soy phytoestrogens. Not one of the available RCTs paperwork a protective impact of phytoestrogens for the clinical finish factors of breast cancer, bone fracture, or cardiovascular occasions. Not one of the compounds investigated thus far have been confirmed to guard towards breast most cancers, bone fracture, or cardiovascular illness. RCTs doc useful effects of phytoestrogens on surrogate parameters reminiscent of bone mineral density, vasodilation, platelet aggregation, insulin resistance, and serum concentrations of triglycerides, high-density lipoprotein, and low-density lipoprotein. In chosen patient populations, reminiscent of in girls with early pure postmenopause and mild to moderate vasomotor signs, a systematic evaluate of 5 RCTs discovered a big discount of sizzling flashes in five out of 5 RCTs. Result(s): Six systematic opinions and meta-analyses of 25 randomized, managed trials (RCTs) assessing the use of phytoestrogens for the therapy of the climacteric syndrome have been identified. Design: Literature research using PubMed and the Cochrane controlled trials register. With the ever rising array of non-public labels, it has opened the doors into the world of trend and general merchandise together with home furnishings, utensils, crockery, cutlery, sports items and rather more at prices that will shock you. VEOXO has the widest vary of electronic items at lowest prices from Handycams, Digital cameras, and so on. of major brands like Sony, Canon Powershot, Olympus, and so forth. All main cell phones can be found at one of the best costs.

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Kudzu (Pueraria Lobata)

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Weed futures: Figuring out present and future weed threats in Australia, Pueraria lobata. Pueraria lobata (Willd) Ohwi (Fig. 1), commonly named kudzu, is an historic Chinese language medicinal plant used for diabetes, alcohol intoxication, stroke, and cardiovascular illness. PlantNET NSW FloraOnline, Pueraria lobata.

PlantNET (The NSW Plant Info Community System). Dig out the tubers and make sure all components of the plant are removed and disposed of appropriately.

Seed split on each sides after they release their seeds.

Pigs can dig out and eat the tubers. Though it is very sensitive to frost, frost-damaged plants can reshoot from tubers in spring. Kudzu plants start producing seeds after three years. Seed viability is mostly low, but sometimes some seeds stay viable for a number of years. Seed split on each sides after they release their seeds. Seeds may be unfold by water, contaminated soil or contaminated fodder or mulch. Lima bean (Phaseolus lunatus), which is usually grown for the edible bean seeds. Hyacinth bean (Lablab purpureus), which is grown for meals and has naturalised in NSW. Kudzu is mostly unfold by folks intentionally planting it for ornamental functions, or for food for folks and livestock. It could even be native to south-east Asia, Papua New Guinea and other Pacific islands but it’s also possible that the plants had been launched to those nations as a food supply. New plants can grow from stems and tubers and plenty of vines can develop from one tuber.

Contaminated soil moved by earth transferring tools can unfold the tubers. Kudzu can climb up bushes and over different buildings up to 30 m high.

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Epidemiological proof suggests potential protective effects of phytoestrogens. Nonetheless, due to mounting evidence that such a declare may be spurious, in December of 2007, the FDA introduced its intent to reevaluate the information justifying this claim 83). In June 30, 2016 the FDA accomplished its analysis of the totality of the present scientific evidence regarding the connection between soy protein and coronary heart illness and is creating a proposed rule with respect to a well being claim authorized in 1999. “The agency has reviewed more than seven-hundred publications identified by means of literature searches, feedback and different info, including data solicited by the FDA in 2007. The FDA plans to publish a proposed rule within the Federal Register and solicit public comments and scientific data concerning the proposal. Various confounding components, nevertheless, including the consumption of chicken that had been fattened with potent estrogens, make the information problematic and difficult to interpret 146). Throughout the last decade, a retrospective cohort research of 952 women discovered that young ladies fed soy-primarily based infant method (248 women) as a part of a managed, College of Iowa feeding examine, reported longer menstrual bleeding and menstrual discomfort than those that had been fed a non-soy-primarily based formula (563 women) 147). On the time the examine was conducted, the women had been too young to comprehensively study pregnancy or fertility outcomes, but, now that almost a decade has previous, this area is ripe for reevaluation. Multiple studies have documented the estrogenic exercise of phytoestrogens in ovariectomized rodents 113) and, in humans, it is generally accepted that consumption of isoflavones-rich soy foods suppresses circulating estrogen and progesterone ranges and can attenuate the preovulatory surge of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) 114). Notably, however, a handful of studies have found no affect of isoflavones on female hormone ranges at all.

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As little as 10 mg of soy per day was sufficient to lower breast cancer risk by 12% 96). This association was not discovered for Caucasian women, however average each day isoflavone intake on this group was significantly decrease (below 1 mg per day). These anti-cancer properties of genistein have been additionally thought-about in 1995 by the Nationwide Cancer Institute (NCI) that beneficial genestein for clinical improvement as a most cancers chemopreventive agent. Genistein and daidzein are additionally produced from the demethylation of their precursors biochanin A and formononetin, respectively. In blood, Isoflavones are metabolized mainly into equol and O-desmethylangolensin (O-DMA) which are excreted in urine. Isoflavones are a subgroup of phytoestrogens, natural plant substances with structure similar to 17-β-estradiol and able to binding to estrogen receptors (ERs). Coumestans show oestrogenic activity, possess a coumarin construction, and are biosynthetically related to isoflavones 29). Coumestans equivalent to coumestrol and 4-methoxycoumestrol are present in mung bean sprouts, brussel sprouts and spinach 30). Coumestrol, crucial coumestan consumed by humans, is present in clover sprouts, alfalfa sprouts, and other legumes. IPLs are available with completely different sized platforms to suit your property. IPLs life far simpler for anybody that makes use of a wheelchair.

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It Accommodates the Best-Known Mixture Of High-potency Phytoestrogen Botanicals

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Phytoestrogens: Finish of A Tale?

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Urinary excretion of lignans and isoflavone phytoestrogens in Japanese women and men consuming a conventional Japanese eating regimen. Kirkman LM, Lampe JW, Campbell D, Martini M,Slavin J. Urinary lignan and isoflavonoid excretion in women and men consuming vegetable and soy diets. Isoflavone levels seen within the NHANES 1999-2004 subsamples had been four to 50 instances lower than levels noticed in Japanese women and men (Adlercreutz et al., 1991; CDC, 2005; Uehara et al., 2000a);Japanese women (Arai et al., 2000); postmenopausal Chinese language ladies (Zheng et al., 1999); Singaporean ladies (Chen et al., 1999; Seow et al., 1998); and Japanese ladies dwelling in Hawaii (Maskarinec et al., 1998). Genistein and daidzein levels in NHANES 1999-2004 subsamples were twice as high as ranges reported in people consuming a carotenoid eating regimen, but decrease than ranges found in people consuming a cruciferous food regimen; O-desmethylangolensin ranges were seven occasions decrease (Kirkman et al., 1995). Levels of genistein, daidzein, and O-desmethylangolensin in urine of individuals consuming a soy eating regimen were 6 to one hundred instances higher than ranges present in NHANES 1999-2004 subsamples (CDC, 2005). Supplementing an omnivorous U.S.

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The concentrations of urinary phytoestrogens noticed in the NHANES 1999-2000, 2000-2001, and 2003-2004 subsamples usually reflect a weight-reduction plan consumed within the U.S. Interindividual variation in metabolism of soy isoflavones and lignans: Affect of habitual food plan on equol production by the gut microflora. Altered time course of urinary daidzein and genistein excretion throughout chronic soya food regimen in healthy male subjects. Dietary soy intake and urinary isoflavone excretion amongst women from a multiethnic population. Comparability of isoflavones among dietary intake, plasma focus and urinary excretion for correct estimation of phytoestrogen intake. Soy-based infant system may end up in plasma concentrations of isoflavones in infants which can be 13,000-22,000 times increased than endogenous estrogen concentrations in infants (Setchell et al., 1997). Phytoestrogens may additionally act by pathways aside from the interplay with estrogen receptors. Plant sources of isoflavones include legumes, with the largest contribution coming from soy-based foods. Usual dietary consumption of soy foods and its correlation with the excretion charge of isoflavonoids in in a single day urine samples among Chinese language ladies in Shanghai. Urinary excretion of isoflavonoids and the risk of breast cancer. Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer threat in European potential investigation of cancer and nutrition-Norfolk. Urinary phytoestrogens and postmenopausal breast most cancers danger. Soybean phytoestrogens intake and cancer threat.

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Affect of soybean processing, habitual weight loss program, and soy dose on urinary isoflavonoid excretion. Urinary isoflavonoid and lignan excretion on a western food regimen: relation to soy, vegetable and fruit intake. Human metabolism of mammalian lignan precursors in raw and processed flaxseed.

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Setchell KDR, Cassidy A. Dietary isoflavones: biological effects and relevance to human health. Finding a measurable quantity of one or more phytoestrogen metabolites in urine doesn’t suggest that the levels of the metabolites or the guardian phytoestrogen trigger an hostile well being effect. Biomonitoring studies on the levels of phytoestrogen metabolites provide physicians and public well being officials with reference values in order that they can decide whether or not folks have been uncovered to greater ranges of phytoestrogens than those present in the overall population. Outcomes of chronic feeding research in pregnant animals suggest that high doses of phytoestrogens alter the fetal hormonal surroundings (Cornwell et al., 2004). Studies of youngsters who had been fed soy-based mostly components as infants and who were followed by way of adolescence (Klein, 1998) and young adulthood (Strom et al., 2001) found no antagonistic reproductive or endocrine results. Adlercreutz et al., 1995a; Dixon and Ferreira, 2002; Sirtori et al., 2005). Numerous studies of both dietary soy or phytoestrogens and health outcomes have demonstrated inconsistent or inconclusive results.

Shocking Details About Pueraria Tuberosa Exposed

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Synonymous with and formerly often called Pueraria lobata. Pueraria montana var. lobata, generally called Kudzu, is a deciduous twining vine that’s famous for its rapid and invasive development. This can be a tuberous vine that establishes large taproots. The voracious nature of this vine has given rise to a number of tongue-in-cheek common names reminiscent of “the vine that ate the South”. Japanese Pavilion at the Philadelphia Centennial Exposition of 1876. Throughout the first half of the 20th century, earlier than its aggressive nature was fully understood, it was broadly planted within the southeastern U.S. It was first introduced into the U.S. Over the previous 100 years, it has escaped cultivation and naturalized in lots of areas of the japanese U.S. Every profitable answer provides up factors that give you stars as soon as the level is over. As you enter any section, a balloon sport initiates with the elementary degree. Four on a moving balloon, it’s essential press 7 earlier than the balloon falls on the bottom. When you have pressed an incorrect answer, you continue to have a margin to correct your enter before the balloon falls. That is probably the most interactive apps that I have seen that may engage your kid to do the fundamental arithmetical calculation in gaming mode.

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These lifelines provide you with further chances even if you enter an incorrect value. Flowers give solution to flattened, bean-like, furry seed pods (to 2” lengthy). Pendant racemes of fragrant, pea-like, purple flowers could appear in late summer season to early fall on plants growing in sun. Flowers are unusual in the northern components of its rising vary, nonetheless. Kudzu can produce prodigious amounts of foliage in optimum situations, growing up to a foot per day and to 100 toes in a single rising season. It is a single-player game but two individuals can also play it level by degree and add up their scores.

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It kinds a crown on the soil stage from which as much as 30 vines may grow, with individual vines extending up to 100’ in size and to 1-4” in diameter.

Pueraria Tuberosa: a Review on Traditional Uses, Pharmacology, And Phytochemistry

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Perfect Curve Body The key phrases used for retrieving related studies had been Pueraria tuberosa plant, Indian Kudzu, vidari kand, tuber extract, conventional makes use of, phytochemical constituents, pharmacological activity, and in silico, in vitro, and in vivo studies. Table 1. Pharmacological actions of tuber extract of Pueraria tuberosa.

Premium Pueraria Mirifica Alcoholic tuber extract of P. tuberosa was studied for anticonvulsant exercise in pentalene tetrazole, strychnine, and maximal electroshock-induced convulsions in animals. The medium and high doses exhibited potent anticonvulsant exercise as in comparison with the management group (Basavaraj et al., 2011). The ethanolic and methanolic extract of leaf, stem, and tuber of P. tuberosa confirmed a wide range of antimicrobial exercise against bacteria, Escherichia coli, Bacillus cereus, Salmonella paratyphi, and Staphylococcus aureus, as well as fungus, Candida albicans, Aspergillus fumigates, and Alternaria solani, on agar diffusion assay (Sadguna et al., 2015). The tuber extracts of P. tuberosa with different solvents exhibited a wide range of antimicrobial activity on chosen bacterial and fungal pathogens (Aruna et al., 2016). The chloroform and water extracts of tuber of P. tuberosa showed important antibacterial activity towards Klebsiella pneumoniae and Staphylococcus aureus and methanolic extract on Staphylococcus aureus and Streptococcus agalactiae (Pandya et al., 2019). The metabolites in P. tuberosa extracts could also be behind the mechanism concerned within the antimicrobial motion, which can work together with the microbial cell membrane resulting in microbial cell dying. These results showed that the methanolic extract of this plant exhibited better activity than the hexane extract in trapping hydroxyl radicals and inhibited lipid peroxidation, which indicated potent antioxidant property (Pandey et al., 2007). Hot water tuber extract of the plant P. tuberosa, supplemented with milk in Swiss mice, confirmed potent antioxidant activities in liver and crimson blood cells. Root extract in male rats.

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Grownup male Wistar rats subjected to chilly immobilization stress, pretreated with 70% hydroethanolic tuber extract of P. tuberosa (200 and 400 mg/kg physique weight) for 5 days, showed significant protection from gastric mucosal damage, decreased corticosterone level within the blood, and no enlargement of spleen and adrenals as in comparison with Withania somnifera (L.) Dunal (Solanaceae) rhizome extract (100 mg/kg body weight). The authors gratefully acknowledge the inspiration for Revitalization of Native Well being Traditions and the University of TransDisciplinary Health Sciences and Technology (FRLHT-TDU) for offering the permission to make use of pictures of P. tuberosa plant from Indian Medicinal Plants database. Indian J. Psych. 55, S273. Flavonoids current in the P. tuberosa tuber extracts have been reported for nootropic impact by interacting with cholinergic, adrenergic, serotonergic, and GABAnergic system (Rao et al., 2008). The neuroprotective properties of this plant had been additionally studied in chronic foot-shock confused rat mannequin displaying unpredictable and inescapable nature of physiological malfunctions, improve in anxiety level, decrease in male sexual indices, and behavioral modifications.

Aside from the traditional makes use of of this plant as talked about in historical literature like Sushruta Samhita (Sanskrit: सुश्रुत संहिता), a number of research have been reported on totally different pharmacological actions of P. tuberosa extracts and its purified compounds, viz., anticancer (Adedapo et al., 2017), anticonvulsant (Basavaraj et al., 2011), antidiabetic (Oza and Kulkarni, 2018a), antifertility (Gupta et al., 2005), anti-inflammatory (Tripathi et al., 2013), antioxidant (Shukla et al., 2018a), anti-stress (Verma et al., 2012), antiulcerogenic (Gindi et al., 2010), cardioprotective (Patel et al., 2018), hypolipidemic (Tanwar et al., 2008), hepatoprotective (Xia et al., 2013), immunomodulatory (Patel et al., 2016), nephroprotective (Shukla et al., 2018b), nootropic (Rao et al., 2008), neuroprotective (Xing et al., 2011), and wound healing activities (Kambhoja and Murthy, 2007). Previously, Maji et al. Elmarakby, A. A., Ibrahim, A. S., Faulkner, J., Mozaffari, M. S., Liou, G. I., and Abdelsayed, R. (2011). Tyrosine kinase inhibitor, genistein, reduces renal inflammation and harm in streptozotocin-induced diabetic mice. Chauhan, N. S., Sharma, V., Thakur, M., Christine Helena Frankland Sawaya, A., and Dixit, V. Ok. (2013). Pueraria tuberosa DC extract improves androgenesis and sexual behavior via FSH LH cascade. Janeesh, P. A., Sasikala, V., Dhanya, C. R., and Abraham, A. (2014). Robinin modulates TLR/NF-κB signaling pathway in oxidized LDL induced human peripheral blood mononuclear cells. Janeesh, P. A., and Abraham, A. (2014). Robinin modulates doxorubicin-induced cardiac apoptosis by TGF-β1 signaling pathway in Sprague Dawley rats.