Keywords: Pueraria mirifica; cynomolgus monkeys; estrogen deficiency; osteoporosis. Changes in bone mass throughout the perimenopausal transition in naturally menopausal cynomolgus monkeys. Generally, changes in the cortical bone geometry have been in the opposite route to the cortical bone mass after PMP1000 therapy. Every 2 months, the bone mineral density (BMD), bone mineral content (BMC) and bone geometry parameters (cortical space and thickness and periosteal and endosteal circumference) on the distal radius and proximal tibia have been decided using peripheral quantitative computed tomography together with plasma and urinary bone markers. Oral PMP treatment might enhance each the bone amount (BMC and BMD) and quality (bone geometry). In distinction, PMP1000 remedy ameliorated the bone loss mainly at the cortical diaphysis by lowering bone turnover, as indicated by the lowered plasma bone-specific alkaline phosphatase and osteocalcin levels. This examine indicated that postmenopausal monkeys repeatedly lose their cortical bone compartment, and they’ve the next risk for long bone fractures.
Compared with the baseline (month 0) values, the cortical, but not trabecular, BMDs and BMCs and the cortical area and thickness on the metaphysis and diaphysis of the radius and tibia of the PMP0 group continuously decreased in the course of the 16-month research period. Mutley Plain
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P. 2022. PMID: 36008958 Free PMC article.
2022. PMID: 35684265 Free PMC article. 2019. PMID: 31824310 Free PMC article. 2018. PMID: 29409850 Evaluation. 2012. PMID: 22460444 Evaluation. Since the in vitro and in vivo anti-osteoporotic effects of Pueraria mirifica (PM) in rodents have been verified, its activity in menopausal monkeys was evaluated as required earlier than it can be relevant for human use. Anti-osteoporotic effects of Pueraria candollei var. Pueraria mirifica, a phytoestrogen-rich herb, prevents bone loss in orchidectomized rats. In this research, postmenopausal osteoporotic monkeys were divided into two groups (5 per group), and fed daily with normal diet alone (PMP0 group) or diet mixed with one thousand mg/kg physique weight (BW) of PM powder (PMP1000 group) for sixteen months. Urasopon N, Hamada Y, Asaoka Ok, Cherdshewasart W, Malaivijitnond S. Urasopon N, et al. Suthon S, Jaroenporn S, Charoenphandhu N, Suntornsaratoon P, Malaivijitnond S. Suthon S, et al. Kittivanichkul D, Watanabe G, Nagaoka Okay, Malaivijitnond S. Kittivanichkul D, et al. Malaivijitnond S. Malaivijitnond S. Front Med. J Nat Med. 2016 Apr;70(2):225-33. 2016 Society for Endocrinology. Biomolecules. 2022 Aug 1;12(8):1064. doi: 10.3390/biom12081064. Biomolecules. Native Wisdom and Diversity of Medicinal Plants in Cha Miang Forest in Mae Kampong Village, Chiang Mai, Thailand, and Their Potential for use as Osteoprotective Products.
