The key phrases used for retrieving relevant studies were Pueraria tuberosa plant, Indian Kudzu, vidari kand, tuber extract, traditional uses, phytochemical constituents, pharmacological activity, and in silico, in vitro, and in vivo research. It’s a rapidly rising giant perennial climber with big tuberous roots (Figures 1-4) (Indian Medicinal Plant Database) and is distributed all through India, Pakistan, and Nepal (Keung, 2002). Lianas of P. tuberosa has also been found to develop at 4,000 feet in the Himalayan mountain series (Pueraria tuberosa-Vikaspedia, 2020). In Ayurveda, it is known as vidari (vidari kand). The extract of this plant may act on mucosal layer of the gastrointestinal, cardiovascular, and nervous (HPA) system, suggestive of anti-stress activity by a discount in stress hormones. Amongst the fashionable civilizations, India has lengthy been known for its rich treasure of medicinal plants, and about greater than 7,000 plant remedies have been categorized and documented by the AYUSH system of drugs (National Medicinal Plants Board, Authorities of India, 2020). One of the medicinally necessary plants mentioned on this evaluation is Pueraria tuberosa (Roxb.
2020). Complete research of the interaction between Puerariae Radix flavonoids and DNA: from theoretical simulation to structural analysis to purposeful evaluation. STZ-induced diabetic rats with nephropathy have been given tuber extract of P. tuberosa (30 mg/a hundred g, body weight) for 20 days and exhibited a big diminished severity of diabetic nephropathy by enhanced expression and activity of MMP-9 and degrading the accumulation of extracellular matrix in kidney tissue (Tripathi et al., 2017). Levels of nephrin, a biomarker of early glomerular injury, in the kidney of diabetic nephropathic rats were restored after therapy with tuber extract of P. tuberosa (Shukla et al., 2017). The diabetic nephropathic inflammatory response is mediated by NF-κB and its activated phosphorylated derivative (pNF-κB). Desk 1. Pharmacological activities of tuber extract of Pueraria tuberosa.
HT-29 human colon carcinoma cell line.
The crude tuber extracts of P. tuberosa are recognized to comprise alkaloids, anthracene, anthocyanidins, anthraquinone, glycosides, carbohydrates, catecholic compounds, coumarins, flavonoids, glycosides, hexose sugars, saponins, steroids, terpenoids, and volatile oils (Ratnam and Venkata Raju, 2009; Rawtal et al., 2019). Therefore, many studies have been undertaken to individually analyze and characterize the activities of different phytoconstituents of the plant. Babu, P. V., Bandi, S., Raju, M., and Tiwari, V. K. (2016). Antioxidant and immunosuppressant exercise of pueraria tuberosa. Aruna, M. R., Kumar, D. J. M., Senbagam, D., and Senthilkumar, B. (2016). Investigation on phytochemical and antimicrobial properties of tuber extracts of pueraria tuberosa linn. Heinrich, M., Appendino, G., Efferth, T., Fürst, R., Izzo, A. A., Kayser, O., et al. Aruna, M. R., Mukesh Kumar, D. J., Palani, P., Senbagam, D., and Senthilkumar, B. (2018). Results of pueraria tuberosa linn hydroalcoholic tuber extract on expression of apoptosis related proteins in HT-29 human colon carcinoma cell line. Fu, X., Qin, T., Yu, J., Jiao, J., Ma, Z., Fu, Q., et al. He, Y., Wu, X., Cao, Y., Hou, Y., Chen, H., Wu, L., et al. Chen, X., He, Z., Wu, X., Mao, D., Feng, C., Zhang, J., et al.
Guo, C. J., Xie, J. J., Hong, R. H., Pan, H. S., Zhang, F. G., and Liang, Y. M. (2019). Puerarin alleviates streptozotocin (STZ)-induced osteoporosis in rats by way of suppressing inflammation and apoptosis by way of HDAC1/HDAC3 signaling. Hua, F., Li, C. H., Chen, X. G., and Liu, X. P. (2018). Daidzein exerts anticancer activity in the direction of SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the Raf/MEK/ERK cascade.