Since I heard that Pueraria Mirifica is a really , very potent phytoestrogen I am trying into taking that one . I do know what you imply concerning the mood swings, but when you’re in this for the long haul, you could be higher taking hrt that can be monitored through blood take a look at to maintain you protected. I am taking 100 mg Spiro and four mg E . Hi Tasha , how long have you been on estrogen and Spiro? I do not believe there may be anything that links PM with cancer prevention, although transwomen on hrt have a decrease risk of testosterone related cancers, and that i believe I read decrease cases of breast most cancers as properly.