Pueraria Candollei variant Mirifica (shortened to Pueraria Mirifica) is one of three herbs given the title of ‘Kwao Krua’, and is known as White Kwao Krua. Based on the preliminary evidence, it does appear promising and effective for menopausal symptoms, but much more research is needed before it can be considered a main opinion. This herb has been traditionally used as a vitality enhancer and rejuvenating agent particularly for older women. When looking at the herb, it is a great source of classical phytoestrogens (including the soy isoflavones) but contains a class of phytoestrogens known as Chromenes that rival estrogen itself in potency. It has been tested numerous times for reducing menopausal symptoms (as estrogen replacement therapy itself is quite effective), and despite the universal promise it shows many studies are not blinded and not run against a placebo; on the topic of menopausal symptoms, this is a significant problem as placebo can be very potent (see Black Cohosh as an example, as the placebo effect in menopause has been reported to reach up to a 50% reduction in symptoms). The herb is highly estrogenic as a result, and is considered the standard herbal ‘estrogen replacement therapy’ due to its potencies. It should be considered a different supplement than Kudzu root, Pueraria Lobata. There is currently no evidence to support the notion that this herb is somehow safer than estrogen replacement therapy, so their benefits and risks should be seen as interchangeable for the time being.
It will be of particular interest to study whether it is these residue variations that differentiate PlUGT43 from type 1 FCGTs in respect of its substrate specificity for isoflavonoids. Logically, daidzein and 2-hydroxyisoflavanone are the most likely substrates for puerarin biosynthesis (Figure 1). Prior to the present study, we had suspected 2-hydroxyisoflavanone to be the substrate, since previous feeding experiments had not suggested a conversion of daidzein to puerarin (Inoue and Fujita, 1977). However, the in vitro biochemical characterization of PlUGT43 reported here suggests that daidzein, rather than 2-hydroxyisoflavanone, is the substrate for C-glucosylation in puerarin biosynthesis (Figures 3 and 4). We have no rational explanation for this inconsistency between the biochemical properties of PlUGT43 and the results of the previous feeding experiments (Inoue and Fujita, 1977). Although it still cannot be completely ruled out that there exists another UGT, distinct from PlUGT43, that C-glucosylates 2-hydroxyisoflavanone for puerarin biosynthesis in P. lobata, we have demonstrated convincingly that PlUGT43 possesses the biochemical activity required to convert daidzein to puerarin. The C-glucosylation for puerarin biosynthesis was previously suggested to take place at the chalcone stage (Figure 1), with isoliquiritigenin being proposed as the direct C-glucosylation acceptor (Inoue and Fujita, 1977; Chen et al., 2010). However, this assertion was not well founded, since C-glucosylated chalcones had not yet been detected from any plant species, and neither CHI nor 2-HIS can convert glycosylated metabolites. To further investigate the role of PlUGT43 in planta, we expressed it in soybean hairy roots that naturally synthesize daidzein and do not produce puerarin.
What Do you want Pueraria Mirifica Cancer To Change into?
Most elderly people often witness bone fracture especially after the ages of 70 or even earlier than that. A bone density test is often conducted to determine the overall chances of developing osteoporosis and also the test suggest the kind of treatment to be given. However such risks will be reduced drastically if an adult ceases to smoke and cut down alcohol intake to the barest minimum. Taking estrogen supplements is believed to be the most ideal way of preventing bone loss in post menopausal women. The most physiological way of slowing down bone loss is through exercises and taking diet supplements such as those that increase the calcium deposit in the bones such as Pueraria Mirifica. Some of the risk factors that predisposes people to bone loss include smoking, excessive alcohol and caffeine consumption, and serious genetic disorders in which the bones are structured abnormally. Women are often advised to increase their dietary intake of foods that boost the presence of Calcium in the body. This herbal supplement can be taken at any period of the day or with any meal. Pueraria Mirifica dietary supplements have been formulated through natural processes that ensure that the natural ingredients of the herbs are protected for maximum efficiency in preventing bone loss. Dietary supplements such as Pueraria Mirifica for instance increase the level of estrogen in the blood and also increase the deposition of mineral deposits which will help prevent bone mass loss or Osteoporosis.
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